Endometrium & Ovary
The currently achievable implantation rate of around 205 per embryo in In vitro Fertilisation (IVF)-treatments is insufficient and could not be improved within the last couple of years. The underlying implantation failure seem to be due to dysregulation of the endometrium, which is still poorly understood and can yet not be treated.
According to previous studies by our research group (Gutsche et al., 2003; Nowak et al., 2007) and by others it can be assumed that seminal plasma, injected into the uterine cavity, can improve endometrial function and thereby increase pregnancy rates (von Wolff et al. 2008). We therefore analyse systematically in vitro the effect of the different constituents of seminal plasma on the regulation of the endometrium as well as the pregnancy rate of IVF-treatments following treatment with seminal plasma.
In IVF-treatments high doses of gonadotropins are typically administered. These gonadotropins are very expensive and can cause a dangerous ovarian hyperstimulation syndrome. We therefore develop new stimulation protocols, which involve only very low amounts of gonadotropins. Furthermore, in these different protocols follicular fluid and granulose cells are analysed by different techniques to study the effect of gonadotropins on ovarian physiology.