Monday, 2021/04/12, 17:00
Bio Oliver Soehnlein is Director of the Institute of Experimental Pathology at the Westfälische Wilhelms-University (WWU), Münster, DE in Münster holds a guest professorship for inflammation physiology at the Karolinska Institutet, Stockholm, Sweden. He received his M.D. in 2004 from the Friedrich-Alexander University of Erlangen, Germany, and his Ph.D. from the Karolinska Institute in 2008. Oliver Soehnlein’s research focuses on understanding the role of myeloid cells in vascular inflammation. Based on this understanding he aims at designing tailored therapeutic approaches.
Abstract Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular disease. However, studies in the past decade have demonstrated the important functions of neutrophils during cardiovascular inflammation and repair. In this talk, I will discuss the current knowledge of the contribution of neutrophils to the different stages of atherosclerosis, including atherogenesis, plaque destabilization and plaque erosion. In the context of cardiovascular complications of atherosclerosis, I will highlight the dichotomous role of neutrophils in pathogenic and repair processes in stroke, heart failure, myocardial infarction and neointima formation. Finally, I will emphasize how detailed knowledge of neutrophil functions in cardiovascular homeostasis and disease can be used to generate therapeutic strategies to target neutrophil numbers, functional status and effector mechanisms.
Website Prof. Dr. Oliver Söhnlein
Host Prof. Dr. Yvonne Döring, Inselspital, Universitätsspital Bern, Departement Herz und Gefässe, Universitätsklinik für Angiologie