Orthopaedic Surgery

(Group Siebenrock)

The activities of the orthopaedic research laboratories in the Department of Clinical Investigation focus on the development of novel therapeutic strategies that are based on biological principles. The envisaged approaches aim at improving and extending the pool of therapeutic tools at the orthopaedic surgeon`s disposal, with a view to improving the life-quality particularly of elderly patients, which is greatly impacted by the functionality of the musculoskeletal system. Thematically, the research topics cover degenerative, traumatic and neoplastic affections of the musculoskeletal system. Our group is especially interested in translational research, particularly in tissue-engineering projects. The goal of this research is to induce the repair of musculoskeletal tissues that do not undergo spontaneous healing, viz., which fail to heal in the absence of extrinsic, growth-factor-based stimulation (e.g., bone, cartilage, tendons and ligaments). Our group is also engaged on research in the basic-medical line, with a view to improving the current understanding of, and gaining novel insights into, the pathophysiology of orthopaedic diseases, and of laying a solid foundation for the conception of new therapeutic approaches. In our laboratories, the methodologies that are implemented to evaluate the data that are gleaned from both in-vitro and in-vivo experiments include histology, stereology, molecular biology, immunology, microcirculatory techniques and intravital microscopy. Clinical research is also undertaken, with a view to improving and further developing current therapies in the interests of our patients.

Please visit the external Group Website for more information.


Tissue Engineering for Orthopaedics & Mechanobiology (TOM)

(Group Gantenbein)

The Tissue Engineering, Orthopaedics & Mechanobiology (TOM) Group of the Department for BioMedical Research (DBMR), at University of Bern, conducts translational research in the intersection of tissue engineering, biology and applied clinical research. The group is knowledgeable in musculoskeletal connective tissues, such as bone, cartilage, ligaments and tendons.

The primary aims of the TOM group are on one the hand to investigate cell therapy options to regenerate the intervertebral disc of the spine and on the other hand, to elucidate bone metabolism and signalling of the bone morphogenic proteins (BMPs) in order to improve patient’s outcome of spinal fusion. To achieve these goals we apply a broad spectrum of methods, such as cell sorting, 3D hydrogel culture, organ 3D culture and specialized bioreactors that maintain the tissue’s mechano-biological requirements.

The common focus of the TOM group is to advance in vitro organ culture models, which match closely the human situation and where regenerative therapy strategies, such as novel biomaterials and cells, can be tested in a most authentic in vitro set-up.

Please visit the external Group Website for more information.

Group Members: 10

Group Siebenrock 4

Group Gantenbein 6