Pulmonary Medicine (Pediatrics)

Main research topics of the Division for pediatric respiratory medicine are:

  • Pathophysiology and early detection of asthma in infants
  • Early detection of pulmonary changes in cystic fibrosis
  • Role of respiratory viruses in exacerbations of chronic airway diseases
  • Improvement of the diagnostics for primary ciliary dyskinesia (PCD)
  • Development of a personalized test approach to screen cystic fibrosis therapeutics
  • Impact of air pollution on the innate respiratory immunity

The development of new lung function techniques and non-invasive markers of airway inflammation is a hallmark of our research. The impact of early airway disease and environmental factors (e.g. air pollution) on the development of the lung can be studied by these new techniques. The BILD cohort (Bern-Basel infant lung development birth cohort), which includes over 450 healthy infants followed from birth on during whole childhood, plays a central role for these studies. The cohort is led in collaboration with Prof. Urs Frey, UKBB, Universitäts-Kinderspital beider Basel, Basel. The role of respiratory viruses in the development and in exacerbations of chronic airway disease is a particular focus of our work.

Another Focus of our research group is the development of a comprehensive diagnostic for primary ciliary dyskinesia (PCD) and of a personalized test approach to screen for efficient cystic fibrosis (CF) therapeutics. Our basic research investigates the impact of air pollution on the innate immunity of the airways, with a special focus on respiratory epithelial cells.

We collaborate closely with researchers from adult pulmonary medicine, from the Institute for Social and Preventive Medicine and from the Institute for Infectious Diseases, as well as with several national and international research groups.
L. Müller

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Group Members: 3