Publications

Prof. Dr. Benjamin Gantenbein

2021

Guerrero J, Häckel S, Croft AS, Albers CE, Gantenbein B. The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency. JOR Spine. 2020 Dec 8;4(1):e1131. doi: 10.1002/jsp2.1131. PMID: 33778405; PMCID: PMC7984018.

Zhang X, Guerrero J, Croft AS, Oswald KAC, Albers CE, Häckel S, Gantenbein B, Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion. Surgeries, 2(1), S. 92-104. MDPI 10.3390/surgeries2010008

Croft AS, Guerrero J, Oswald KAC, Häckel S, Albers CE, Gantenbein B. Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential. JOR Spine. 2021 Feb 14;4(1):e1140. doi: 10.1002/jsp2.1140. PMID: 33778412; PMCID: PMC7983999.

Croft AS, Illien-Jünger S, Grad S, Guerrero J, Wangler S, Gantenbein B. The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc. Int J Mol Sci. 2021 Mar 29;22(7):3519. doi: 10.3390/ijms22073519. PMID: 33805356; PMCID: PMC8036861.

Gantenbein, B.; May, R.D.; Bermudez-Lekerika, P.; Oswald, K.A.C.; Benneker, L.M.; Albers, C.E. EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs. Appl. Sci. 2021, 11, 4072. https://doi.org/10.3390/app11094072

Guerrero J, Häckel S, Croft AS, Albers CE, Gantenbein, B. (2021). GP16: The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency (Unveröffentlicht). In: ISSLS Virtual Meeting. Milano. 2-4 June 2021.

Croft AS, Guerrero J, Oswald KAC, Häckel S, Albers CE, Gantenbein, B. (2021). GP014: Effect of different Cryopreservation Media on Human Nucleus Pulposus Cells' Viability and Trilineage Potential (Unveröffentlicht). In: ISSLS Virtual Meeting. Milano, italy. 2-4 June 2021.

Guerrero J, Häckel S, Croft AS, Hoppe S, Albers CE, Gantenbein B. The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth? Eur Cell Mater. 2021 Jun 15;41:707-738. doi: 10.22203/eCM.v041a46. PMID: 34128534.

2020

Zhang X, Guerrero J, Croft AS, Albers CE, Häckel S, Gantenbein B. Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc. Int J Mol Sci. 2020 Dec 10;21(24):9423. doi: 10.3390/ijms21249423. PMID: 33322051; PMCID: PMC7763454.

Schmidli MR, Sadowska A, Cvitas I, Gantenbein B, Lischer HEL, Forterre S, Hitzl W, Forterre F, Wuertz-Kozak K. Fibronectin Fragments and Inflammation During Canine Intervertebral Disc Disease. Front Vet Sci. 2020 Nov 16;7:547644. doi: 10.3389/fvets.2020.547644. PMID: 33304936; PMCID: PMC7701143.

Gantenbein B, Croft AS, Larraillet M. Mammalian Cell Viability Methods in 3D Scaffolds for Tissue Engineering. In: Grigoryeva, Natalia (Hg.) Fluorescence Methods for Investigation of Living Cells and Microorganisms. Rijeka: IntechOpen (2020) 10.5772/intechopen.93078

Bakirci E, Tschan K, May RD, Ahmad SS, Kleer B, Gantenbein B. The importance of plasmin for the healing of the anterior cruciate ligament. Bone Joint Res. 2020 Sep 3;9(9):543-553. doi: 10.1302/2046-3758.99.BJR-2020-0048.R1. PMID: 32922763; PMCID: PMC7469513.

May RD, Frauchiger DA, Albers CE, Hofstetter W, Gantenbein B. Exogenous Stimulation of Human Intervertebral Disc Cells in 3-Dimensional Alginate Bead Culture With BMP2 and L51P: Cytocompatibility and Effects on Cell Phenotype. Neurospine. 2020 Mar;17(1):77-87. doi: 10.14245/ns.2040002.001. Epub 2020 Mar 31. PMID: 32252157; PMCID: PMC7136110.

Croft AS, Guerrero J, Häckel S, Oberli A, Graf S, Zhang X, Benneker LM, Sakai D, Tryfonidou M, Gantenbein B. Trilineage Potency of Human Nucleus Pulposus Cells before and after Cryo-Preservation. eCM online periodical, 2020, P247-P247. Manchester: AO Foundation

Gantenbein B, Guerrero J, Graf S, May RD, Bidgon S, Klenke FM, Deml MC, Albers CE. BMP Antagonists - A Possible Cause for Spinal Non-Fusion? eCM online periodical, 2020, S. 143. Manchester: AO Foundation

Zhang X, Guerrero J, Häckel S, Croft AS, Graf S, Oberli A, Sakai D, Tryfonidou M, Benneker LM, Gantenbein B. Spheroid-like Cultures for Cell Expansion of Angiopoietin Receptor-1 (aka. Tie2) positive Cells from the human Intervertebral Disc. eCM online periodical, 2020, S. 248. Manchester: AO Foundation

Guerrero J, Häckel S, Croft AS, Graf S, Oberli A, Zhang X, Benneker LM, Sakai D, Tryfonidou M, Gantenbein B. Mimicking the Intervertebral Disc Microenvironment for Expansion of Nucleus Pulposus Progenitor Cells in a Context of Cell Therapy. eCM online periodical, 2020, S. 146. Manchester: AO Foundation

Gantenbein B, Tang S, Guerrero J, Higuita-Castro N, Salazar-Puerta AI, Croft AS, Gazdhar A, Purmessur D. Non-viral Gene Delivery Methods for Bone and Joints. Front Bioeng Biotechnol. 2020 Nov 19;8:598466. doi: 10.3389/fbioe.2020.598466. PMID: 33330428; PMCID: PMC7711090.

Gantenbein B, Guerrero JP. Promoting biological therapy in orthopaedic research. Leading Opinions in Orthopädie & Rheumatology, 2020(1), S. 10-13.

2019

Frauchiger DA, Tekari A, May RD, Džafo E, Chan SCW, Stoyanov J, Bertolo A, Zhang X, Guerrero J, Sakai D, Schol J, Grad S, Tryfonidou M, Benneker LM, Gantenbein B. Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods. Tissue Eng Part C Methods. 2019 Oct;25(10):571-580. doi: 10.1089/ten.TEC.2018.0375. Epub 2019 Sep 9. PMID: 31154900.

Gantenbein B, Guerrero J, (September 2019). Better solutions for the replacement of joints. Scitech Europa

May RD, Frauchiger DA, Albers CE, Tekari A, Benneker LM, Klenke FM, Hofstetter W, Gantenbein B. Application of Cytokines of the Bone Morphogenetic Protein (BMP) Family in Spinal Fusion - Effects on the Bone, Intervertebral Disc and Mesenchymal Stromal Cells. Curr Stem Cell Res Ther. 2019;14(8):618-643. doi: 10.2174/1574888X14666190628103528. PMID: 31455201; PMCID: PMC7040507.

Gantenbein B, Frauchiger DA, May RD, Bakirci E, Rohrer U, Grad S, (2019). Developing Bioreactors to Host Joint-Derived Tissues That Require Mechanical Stimulation. In: Reference Module in Biomedical Sciences. Elsevier 10.1016/B978-0-12-801238-3.65611-8

Kehl D, Generali M, Mallone A, Heller M, Uldry AC, Cheng P, Gantenbein B, Hoerstrup SP, Weber B. Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential. NPJ Regen Med. 2019 Apr 16;4:8. doi: 10.1038/s41536-019-0070-y. PMID: 31016031; PMCID: PMC6467904.

Frauchiger DA, Tekari A, May R, Dzafo E, Chan SCW, Stoyanov J, Bertolo A, Zhang X, Sakai D, Schol J, Grad S, Tryfonidou M, Benneker LM, Gantenbein B, (2019). Different isolation methods for nucleus pulposus progenitor cells. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April 2019.

May RD, Frauchiger DA, Albers CE, Benneker LM, Gantenbein B, (2019). Changes in gene expression of intervertebral discs from diffuse idiopathic skeletal hyperostosis (DISH) patients compared to traumatic/degenerative intervertebral discs. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April.

May RD, Frauchiger DA, Albers CE, Benneker LM, Hofstetter W, Gantenbein B, (2019). Stimulation of intervertebral disc cells in alginate bead culture with bone morphogenetic protein 2 and/or L51P. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). 3-5 April.

Zhang X, Frauchiger DA, May RD, Dzafo E, Tekari A, Benneker LM, Sakai D, Tryfonidou M, Gantenbein B, (2019). Can PPARδ agonist increase cell yield of nucleus pulposus progenitor cells positive for angiopoietin-1 receptor (= TIE2) after cell isolation? In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April.

Gantenbein B, (2019). Invited Keynote: Exploring progenitor cell therapies for the intervertebral disc (Unveröffentlicht). In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April.

Tekari A, Chan SCW, Sakai D, Grad S, Gantenbein B. Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Stem Cell Res Ther. 2019 Jan 31;10(1):49. doi: 10.1186/s13287-019-1150-z. Erratum for: Stem Cell Res Ther. 2016 May 23;7(1):75. PMID: 30704506; PMCID: PMC6357447.

May RD, Frauchiger DA, Albers CE, Benneker LM, Hofstetter W, Gantenbein B, (2019). Changes in Gene Expression of Discs from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Patients Compared to Traumatic/Degenerative Discs. In: TERMIS EU chapter meeting. Rhodes, Greece. 27th-31st May 2019.

Dzafo E, May R, Müller EJ, Baertschi S, Naveiras O, Benneker LM, Gantenbein B, (2019). Investigation of the effect of nicotinamide riboside on primary human bone-marrow derived mesenchymal stromal cells in vitro. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). Rom, Italy. 3-5 April.

May RD, Frauchiger DA, Albers CE, Benneker LM, Hofstetter W, Gantenbein B, (2019). Stimulation of intervertebral disc cells in alginate bead culture with bone morphogenetic protein 2 and/or L51P. In: TERMIS EU chapter meeting. Rhodes, Greece. 27th-31s tMay.

Gantenbein B, (2019). Invited Keynote: Nucleus Pulposus Progenitor Cells positive for Receptor Angiopoietin-1 alias Tie2 Multipotent Cells of Specific Capabilities for Tissue Engineering? In: TERMIS EU. 27th-31st May 2019.

Frauchiger DA, May RD, Dzafo E, Zhang X, Stoyanov J, Bertolo A, Benneker LM, Sakai D, Grad S, Tryfonidou MA, Gantenbein B, (2019). FACS reveals more Pluripotent Intervertebral Disc Progenitor Cells compared to MACS and pluriSelect. In: TERMIS European Chapter Meeting 2019 (S. 898). Davos eCMjournal: www.ecmjournal.org

Dzafo E, May RD, Müller EJ, Baertschi S, Naveiras O, Benneker LM, Gantenbein B, (2019). Investigation of the effect of nicotinamide riboside on primary human bone-marrow derived mesenchymal stromal cells in vitro. In: TERMIS European Chapter Meeting 2019. 27th-31st May 2019

Prof. Dr. Willy Hofstetter

2020

Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbären N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nat Metab. 2020 Aug;2(8):688-702. doi: 10.1038/s42255-020-0228-3. Epub 2020 Jul 6. PMID: 32694825; PMCID: PMC7438316.

Saulacic N, Muñoz F, Kobayashi E, Chappuis V, Gonzáles-Cantalapiedra A, Hofstetter W. Effects of local application of alendronate on early healing of extraction socket in dogs. Clin Oral Investig. 2020 Apr;24(4):1579-1589. doi: 10.1007/s00784-019-03031-7. Epub 2019 Jul 26. PMID: 31346723.

May RD, Frauchiger DA, Albers CE, Hofstetter W, Gantenbein B. Exogenous Stimulation of Human Intervertebral Disc Cells in 3-Dimensional Alginate Bead Culture With BMP2 and L51P: Cytocompatibility and Effects on Cell Phenotype. Neurospine. 2020 Mar;17(1):77-87. doi: 10.14245/ns.2040002.001. Epub 2020 Mar 31. PMID: 32252157; PMCID: PMC7136110.

2019

May RD, Frauchiger DA, Albers CE, Tekari A, Benneker LM, Klenke FM, Hofstetter W, Gantenbein B. Application of Cytokines of the Bone Morphogenetic Protein (BMP) Family in Spinal Fusion - Effects on the Bone, Intervertebral Disc and Mesenchymal Stromal Cells. Curr Stem Cell Res Ther. 2019;14(8):618-643. doi: 10.2174/1574888X14666190628103528. PMID: 31455201; PMCID: PMC7040507.

Zhao W, Michalik D, Ferguson S, Hofstetter W, Lemaître J, von Rechenberg B, Bowen P. Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method. Nat Commun. 2019 May 2;10(1):2062. doi: 10.1038/s41467-019-09673-1. PMID: 31048680; PMCID: PMC6497645.

Gallo M, Le Gars Santoni B, Douillard T, Zhang F, Gremillard L, Dolder S, Hofstetter W, Meille S, Bohner M, Chevalier J, Tadier S. Effect of grain orientation and magnesium doping on β-tricalcium phosphate resorption behavior. Acta Biomater. 2019 Apr 15;89:391-402. doi: 10.1016/j.actbio.2019.02.045. Epub 2019 Mar 1. PMID: 30831328.

May RD, Frauchiger DA, Albers CE, Benneker LM, Hofstetter W, Gantenbein B, (2019). Stimulation of intervertebral disc cells in alginate bead culture with bone morphogenetic protein 2 and/or L51P. In: 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7). 3-5 April.

May RD, Frauchiger DA, Albers CE, Benneker LM, Hofstetter W, Gantenbein B, (2019). Stimulation of intervertebral disc cells in alginate bead culture with bone morphogenetic protein 2 and/or L51P. In: TERMIS EU chapter meeting. Rhodes, Greece. 27th-31s tMay.

2018

Hauser M, Siegrist M, Denzer A, Saulacic N, Grosjean J, Bohner M, Hofstetter W. Bisphosphonates reduce biomaterial turnover in healing of critical-size rat femoral defects. J Orthop Surg (Hong Kong). 2018 May-Aug;26(3):2309499018802487. doi: 10.1177/2309499018802487. PMID: 30270749.

Moor MB, Ramakrishnan SK, Legrand F, Dolder S, Siegrist M, Durussel F, Centeno G, Firsov D, Hynes NE, Hofstetter W, Bonny O. Redox-Dependent Bone Alkaline Phosphatase Dysfunction Drives Part of the Complex Bone Phenotype in Mice Deficient for Memo1. JBMR Plus. 2018 Jul;2(4):195-205. doi: 10.1002/jbm4.10034. Epub 2018 Jan 17. PMID: 30038965; PMCID: PMC6054794.

Hauser M, Siegrist M, Keller I, Hofstetter W. Healing of fractures in osteoporotic bones in mice treated with bisphosphonates - A transcriptome analysis. Bone. 2018 Jul;112:107-119. doi: 10.1016/j.bone.2018.04.017. Epub 2018 Apr 20. PMID: 29680263.

Uster S, Coelho FM, Aeberli D, Stein JV, Hofstetter W, Engelhardt B, Seitz M. TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply. Bone. 2018 Feb;107:56-65. doi: 10.1016/j.bone.2017.10.020. Epub 2017 Nov 14. PMID: 29081378.