Publications

Link to website showing complete list of publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Hediger%20MA *) Co-Corresponding author

2021

Kandasamy P, Zlobec I, Nydegger DT, Pujol-Giménez J, Bhardwaj R, Shirasawa S, Tsunoda T, Hediger MA. Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. Mol Oncol. 2021 May 18. doi: 10.1002/1878-0261.12999. Epub ahead of print. PMID: 34003553. (in press).

Kar P, Lin YP, Bhardwaj R, Tucker CJ, Bird GS, Hediger MA, Monico C, Amin N, Parekh AB. The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2012908118. doi: 10.1073/pnas.2012908118. PMID: 33941685; PMCID: PMC8126794. (in press).

2020

Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin KD, Singh AK, Cunha MR, Derler I, Gyimesi G, Reymond JL, Hediger MA, Romanin C, Sobolevsky AI. Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv. 2020 Nov 27;6(48):eabe1508. doi: 10.1126/sciadv.abe1508. PMID: 33246965; PMCID: PMC7695471.

Gyimesi G, Hediger MA. Sequence Features of Mitochondrial Transporter Protein Families. Biomolecules. 2020 Nov 28;10(12):1611. doi: 10.3390/biom10121611. PMID: 33260588; PMCID: PMC7761412.

Gibhardt CS, Cappello S, Bhardwaj R, Schober R, Kirsch SA, Bonilla Del Rio Z, Gahbauer S, Bochicchio A, Sumanska M, Ickes C, Stejerean-Todoran I, Mitkovski M, Alansary D, Zhang X, Revazian A, Fahrner M, Lunz V, Frischauf I, Luo T, Ezerina D, Messens J, Belousov VV, Hoth M, Böckmann RA, Hediger MA, Schindl R, Bogeski I. Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. Cell Rep. 2020 Oct 20;33(3):108292. doi: 10.1016/j.celrep.2020.108292. PMID: 33086068.

Anderegg MA, Albano G, Hanke D, Deisl C, Uehlinger DE, Brandt S, Bhardwaj R, Hediger MA, Fuster DG. The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney. Kidney Int. 2021 Feb;99(2):350-363. doi: 10.1016/j.kint.2020.08.023. Epub 2020 Sep 18. PMID: 32956652.

Schild A, Bhardwaj R, Wenger N, Tscherrig D, Kandasamy P, Dernič J, Baur R, Peinelt C, Hediger MA, Lochner M. Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. Int J Mol Sci. 2020 Aug 5;21(16):5604. doi: 10.3390/ijms21165604. PMID: 32764353; PMCID: PMC7460636.

Cunha MR, Bhardwaj R, Carrel AL, Lindinger S, Romanin C, Parise-Filho R, Hediger MA, Reymond JL. Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Med Chem. 2020 Jul 16;11(9):1032-1040. doi: 10.1039/d0md00145g. PMID: 33479695; PMCID: PMC7513592.

Gyimesi G, Pujol-Giménez J, Kanai Y, Hediger MA. Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application. Pflugers Arch. 2020 Sep;472(9):1177-1206. doi: 10.1007/s00424-020-02433-x. Epub 2020 Aug 7. PMID: 32767111; PMCID: PMC7462921.

Poirier M, Pujol-Giménez J, Manatschal C, Bühlmann S, Embaby A, Javor S, Hediger MA, Reymond JL. Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation. RSC Med Chem. 2020 Jun 2;11(9):1023-1031. doi: 10.1039/d0md00085j. PMID: 33479694; PMCID: PMC7649969.

Bhardwaj R, Augustynek BS, Ercan-Herbst E, Kandasamy P, Seedorf M, Peinelt C, Hediger MA. Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. Cell Physiol Biochem. 2020 Mar 17;54(2):252-270. doi: 10.33594/000000218. PMID: 32176842.

2019

Manatschal C, Pujol-Giménez J, Poirier M, Reymond JL, Hediger MA, Dutzler R. Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. Elife. 2019 Dec 5;8:e51913. doi: 10.7554/eLife.51913. PMID: 31804182; PMCID: PMC6917499.

Cunha MR, Bhardwaj R, Lindinger S, Butorac C, Romanin C, Hediger MA, Reymond JL. Photoswitchable Inhibitor of the Calcium Channel TRPV6. ACS Med Chem Lett. 2019 Aug 2;10(9):1341-1345. doi: 10.1021/acsmedchemlett.9b00298. PMID: 31531207; PMCID: PMC6746075.

Lüscher BP, Surbek DV, Clémençon B, Huang X, Albrecht C, Marini C, Hediger MA, Baumann MU. Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia. Cell Physiol Biochem. 2019;53(3):508-517. doi: 10.33594/000000154. PMID: 31502429.

Pereira GJV, Tavares MT, Azevedo RA, Martins BB, Cunha MR, Bhardwaj R, Cury Y, Zambelli VO, Barbosa EG, Hediger MA, Parise-Filho R. Capsaicin-like analogue induced selective apoptosis in A2058 melanoma cells: Design, synthesis and molecular modeling. Bioorg Med Chem. 2019 Jul 1;27(13):2893-2904. doi: 10.1016/j.bmc.2019.05.020. Epub 2019 May 14. PMID: 31104785.

Stergachis AB, Pujol-Giménez J, Gyimesi G, Fuster D, Albano G, Troxler M, Picker J, Rosenberg PA, Bergin A, Peters J, El Achkar CM, Harini C, Manzi S, Rotenberg A, Hediger MA, Rodan LH. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019 Jun;85(6):921-926. doi: 10.1002/ana.25477. Epub 2019 Apr 26. PMID: 30937933; PMCID: PMC6800210.

Gyimesi G, Albano G, Fuster DG, Hediger MA, Pujol-Giménez J. Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2). J Biol Chem. 2019 May 17;294(20):8046-8063. doi: 10.1074/jbc.RA118.006113. Epub 2019 Mar 26. Erratum in: J Biol Chem. 2020 Mar 27;295(13):4369. Erratum in: J Biol Chem. 2020 Mar 27;295(13):4369. PMID: 30914478; PMCID: PMC6527156.

Butorac C, Muik M, Derler I, Stadlbauer M, Lunz V, Krizova A, Lindinger S, Schober R, Frischauf I, Bhardwaj R, Hediger MA, Groschner K, Romanin C. A novel STIM1-Orai1 gating interface essential for CRAC channel activation. Cell Calcium. 2019 May;79:57-67. doi: 10.1016/j.ceca.2019.02.009. Epub 2019 Feb 23. PMID: 30831274.

Bulla M, Gyimesi G, Kim JH, Bhardwaj R, Hediger MA, Frieden M, Demaurex N. ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain. J Physiol. 2019 Jan;597(2):561-582. doi: 10.1113/JP277079. Epub 2018 Nov 28. PMID: 30382595; PMCID: PMC6332830.