Ganal-Vonarburg Lab

Ganal-Vonarburg Lab



Kalbermatter, C., Fernandez Trigo, N., Christensen, S., and Ganal-Vonarburg, S.C. (2021). Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn. Front Immunol 12, 683022.

Yilmaz, B., Mooser, C., Keller, I., Li, H., Zimmermann, J., Bosshard, L., Fuhrer, T., Gomez de Aguero, M., Trigo, N.F., Tschanz-Lischer, H., Limenitakis, J.P., Hardt, W.D., McCoy, K.D., Stecher, B., Excoffier, L., Sauer, U., Ganal-Vonarburg, S.C., and Macpherson, A.J. (2021). Long-term evolution and short-term adaptation of microbiota strains and sub-strains in mice. Cell Host Microbe 29, 650-663 e659.

Pownall, W.R., Imhof, D., Trigo, N.F., Ganal-Vonarburg, S.C., Plattet, P., Monney, C., Forterre, F., Hemphill, A., and Oevermann, A. (2021). Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1). Front Cell Infect Microbiol 11, 675219.

Sanchez-Taltavull, D., Castelo-Szekely, V., Murugan, S., Hamley, J.I.D., Rollenske, T., Ganal-Vonarburg, S.C., Buchi, I., Keogh, A., Li, H., Salm, L., Spari, D., Yilmaz, B., Zimmermann, J., Gerfin, M., Roldan, E., Beldi, G., and researchers, U.-C. (2021). Regular testing of asymptomatic healthcare workers identifies cost-efficient SARS-CoV-2 preventive measures. PLoS One 16, e0258700.


Li, H., Limenitakis, J.P., Greiff, V., Yilmaz, B., Scharen, O., Urbaniak, C., Zund, M., Lawson, M.A.E., Young, I.D., Rupp, S., Heikenwalder, M., McCoy, K.D., Hapfelmeier, S., Ganal-Vonarburg, S.C.*, and Macpherson, A.J.* (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature 584, 274-278. *Co-last and co-corresponding author

Schaupp, L., Muth, S., Rogell, L., Kofoed-Branzk, M., Melchior, F., Lienenklaus, S., Ganal-Vonarburg, S.C., Klein, M., Guendel, F., Hain, T., Schutze, K., Grundmann, U., Schmitt, V., Dorsch, M., Spanier, J., Larsen, P.K., Schwanz, T., Jackel, S., Reinhardt, C., Bopp, T., Danckwardt, S., Mahnke, K., Heinz, G.A., Mashreghi, M.F., Durek, P., Kalinke, U., Kretz, O., Huber, T.B., Weiss, S., Wilhelm, C., Macpherson, A.J., Schild, H., Diefenbach, A., and Probst, H.C. (2020). Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Cell 181, 1080-1096 e1019.

Ganal-Vonarburg, S.C., Hornef, M.W., and Macpherson, A.J. (2020). Microbial-host molecular exchange and its functional consequences in early mammalian life. Science 368, 604-607.

Ganal-Vonarburg, S.C., and Duerr, C.U. (2020). The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life. Immunology 159, 39-51.

Mezo, C., Dokalis, N., Mossad, O., Staszewski, O., Neuber, J., Yilmaz, B., Schnepf, D., de Aguero, M.G., Ganal-Vonarburg, S.C., Macpherson, A.J., Meyer-Luehmann, M., Staeheli, P., Blank, T., Prinz, M., and Erny, D. (2020). Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease. Acta Neuropathol Commun 8, 119.

Roder, T., Wuthrich, D., Bar, C., Sattari, Z., Ah, U.V., Ronchi, F., Macpherson, A.J., Ganal-Vonarburg, S.C., Bruggmann, R., and Vergeres, G. (2020). In Silico Comparison Shows that the Pan-Genome of a Dairy-Related Bacterial Culture Collection Covers Most Reactions Annotated to Human Microbiomes. Microorganisms 8.


Grootjans, J., Krupka, N., Hosomi, S., Matute, J.D., Hanley, T., Saveljeva, S., Gensollen, T., Heijmans, J., Li, H., Limenitakis, J.P., Ganal-Vonarburg, S.C., Suo, S., Luoma, A.M., Shimodaira, Y., Duan, J., Shih, D.Q., Conner, M.E., Glickman, J.N., Fuhler, G.M., Palm, N.W., de Zoete, M.R., van der Woude, C.J., Yuan, G.C., Wucherpfennig, K.W., Targan, S.R., Rosenstiel, P., Flavell, R.A., McCoy, K.D., Macpherson, A.J., Kaser, A., and Blumberg, R.S. (2019). Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science 363, 993-998.

Mooser, C., and Ganal-Vonarburg, S.C. (2019). Microbiota as a cornerstone in the development of primary sclerosing cholangitis: paving the path for translational diagnostic and therapeutic approaches. Gut 68, 1353-1355.


Uchimura, Y., Fuhrer, T., Li, H., Lawson, M.A., Zimmermann, M., Yilmaz, B., Zindel, J., Ronchi, F., Sorribas, M., Hapfelmeier, S., Ganal-Vonarburg, S.C., Gomez de Aguero, M., McCoy, K.D., Sauer, U., and Macpherson, A.J. (2018). Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response. Immunity 49, 545-559 e545.

Mooser, C., Gomez de Aguero, M., and Ganal-Vonarburg, S.C. (2018). Standardization in host-microbiota interaction studies: challenges, gnotobiology as a tool, and perspective. Curr Opin Microbiol 44, 50-60.

Bauche, D., Joyce-Shaikh, B., Jain, R., Grein, J., Ku, K.S., Blumenschein, W.M., Ganal-Vonarburg, S.C., Wilson, D.C., McClanahan, T.K., Malefyt, R.W., Macpherson, A.J., Annamalai, L., Yearley, J.H., and Cua, D.J. (2018). LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity 49, 342-352 e345.

Macpherson, A.J., Yilmaz, B., Limenitakis, J.P., and Ganal-Vonarburg, S.C. (2018). IgA Function in Relation to the Intestinal Microbiota. Annu Rev Immunol 36, 359-381.

Girard-Madoux, M.J.H., Gomez de Aguero, M., Ganal-Vonarburg, S.C., Mooser, C., Belz, G.T., Macpherson, A.J., and Vivier, E. (2018). The immunological functions of the Appendix: An example of redundancy? Semin Immunol 36, 31-44.

Macpherson, A.J., and Ganal-Vonarburg, S.C. (2018). Checkpoint for gut microbes after birth. Nature 560, 436-438.

Macpherson, A.J., and Ganal-Vonarburg, S.C. (2018). IgA-about the unexpected. J Exp Med 215, 1965-1966.


Macpherson, A.J., de Aguero, M.G., and Ganal-Vonarburg, S.C. (2017). How nutrition and the maternal microbiota shape the neonatal immune system. Nat Rev Immunol 17, 508-517.

Ganal-Vonarburg, S.C., Fuhrer, T., and Gomez de Aguero, M. (2017). Maternal microbiota and antibodies as advocates of neonatal health. Gut Microbes 8, 479-485.


Gomez de Aguero*, M., Ganal-Vonarburg, S.C.*, Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., McCoy, K.D., and Macpherson, A.J. (2016). The maternal microbiota drives early postnatal innate immune development. Science 351, 1296-1302. *Co-first author

Macpherson, A.J., Heikenwalder, M., and Ganal-Vonarburg, S.C. (2016). The Liver at the Nexus of Host-Microbial Interactions. Cell Host Microbe 20, 561-571.

Ganal-Vonarburg, S.C., and Macpherson, A.J. (2016). Our Mothers' Antibodies as Guardians of our Commensals. Trends Mol Med 22, 739-741.


Li, H., Limenitakis, J.P., Ganal, S.C., and Macpherson, A.J. (2015). Penetrability of the inner mucus layer: who is out there? EMBO Rep 16, 127-129.


Ganal, S.C., and MacPherson, A.J. (2014). An ambulance for retinol. Elife 3, e04246.


Ganal, S.C., Sanos, S.L., Kallfass, C., Oberle, K., Johner, C., Kirschning, C., Lienenklaus, S., Weiss, S., Staeheli, P., Aichele, P., and Diefenbach, A. (2012). Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity 37, 171-186.

Ayata, C.K., Ganal, S.C., Hockenjos, B., Willim, K., Vieira, R.P., Grimm, M., Robaye, B., Boeynaems, J.M., Di Virgilio, F., Pellegatti, P., Diefenbach, A., Idzko, M., and Hasselblatt, P. (2012). Purinergic P2Y(2) receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterology 143, 1620-1629 e1624.

Raifer, H., Mahiny, A.J., Bollig, N., Petermann, F., Hellhund, A., Kellner, K., Guralnik, A., Reinhard, K., Bothur, E., Huber, M., Bauer, S., Lohning, M., Kiss, E.A., Ganal, S.C., Diefenbach, A., Korn, T., and Lohoff, M. (2012). Unlike alphabeta T cells, gammadelta T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. Eur J Immunol 42, 3189-3201.


Puga, I., Cols, M., Barra, C.M., He, B., Cassis, L., Gentile, M., Comerma, L., Chorny, A., Shan, M., Xu, W., Magri, G., Knowles, D.M., Tam, W., Chiu, A., Bussel, J.B., Serrano, S., Lorente, J.A., Bellosillo, B., Lloreta, J., Juanpere, N., Alameda, F., Baro, T., de Heredia, C.D., Toran, N., Catala, A., Torrebadell, M., Fortuny, C., Cusi, V., Carreras, C., Diaz, G.A., Blander, J.M., Farber, C.M., Silvestri, G., Cunningham-Rundles, C., Calvillo, M., Dufour, C., Notarangelo, L.D., Lougaris, V., Plebani, A., Casanova, J.L., Ganal, S.C., Diefenbach, A., Arostegui, J.I., Juan, M., Yague, J., Mahlaoui, N., Donadieu, J., Chen, K., and Cerutti, A. (2011). B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen. Nat Immunol 13, 170-180.