Translational Cancer Research
This research cluster is designed to take maximum advantage of the synergies between relevant disciplines involved in cancer research at the Department for BioMedical Research and the Bern University Hospital, Inselspital. The cluster brings together the research labs of Medical Oncology (Ochsenbein, Riether, Pabst, Seipel, Novak, Häfliger, Berger), Radiation Oncology (Aebersold, Medová, Zimmer) and Pediatric Hematology / Oncology (Rössler/Bernasconi). It combines cutting-edge RNA and CRISPR research (Häfliger), with state-of-the art cancer organoid culture, cancer modelling and immunotherapy (Ochsenbein, Riether, Pabst, Novak, Zimmer, Medová, Rössler, Bernasconi), targeted Nanomedicine (Rössler, Bernasconi) as well as studying of treatment responses (Pabst, Zimmer, Medová, Aebersold, Seipel, Berger, Novak). In this respect, particular emphasis resides in studies of resistance mechanisms associated with treatment modalities consisting of DNA-damaging agents and inhibitors targeting receptor tyrosine kinases and the DNA damage response machinery.