Decoding regenerative failure across scales
The Gote-Schniering Lab investigates how chronic inflammation and immune ageing disrupt the body’s capacity to regenerate after injury. Using the lung as a model organ, we seek to understand why tissue repair fails and ultimately gives way to progressive fibrosis in chronic inflammatory and fibrotic diseases.
Our research spans biological scales, from the whole organ to individual cells and their molecular interactions, and integrates advanced imaging, single-cell and spatial multiomics, human 3D tissue models, and deeply phenotyped patient cohorts. By connecting tissue architecture with cellular phenotypes and molecular mechanisms, we aim to identify the multicellular circuits that determine whether injured tissue regenerates or progresses towards irreversible fibrosis.
Our work lies at the interface of immunology, rheumatology, respiratory medicine and computational biology. Rather than studying individual cell types or isolated pathways, we seek to understand disease as a dynamic multicellular system that evolves across molecular, cellular, tissue and clinical scales.
Ultimately, our goal is to translate these discoveries into biomarkers, predictive models and mechanism-based therapies that enable earlier intervention and more precise treatment for patients with chronic inflammatory and fibrotic diseases.
