METALLO DRUGS AND CELL BIOLOGY
For several decades, metal-based drugs have been used in cancer treatment or as contrast agents in imaging analysis procedures. Nevertheless, there are still many unanswered questions, especially regarding their effect at the cellular level. For example, the development of resistance to cisplatin, which represents the first-line treatment for lung cancer chemotherapy, is still largely a closed book. The latter also applies to contrast agents containing Gadolinium, especially since reports of Gadolinium deposits in the brain have been published. There are still many unanswered questions that govern our research. A variety of methods are used to answer them, ranging from classical biochemical and cell biological methods to modern analytical methods, e.g. single cell ICP-MS, and bioinformatics.
For more information please also visit the “Insel” Group Website: Experimentelle Radiologie - Radiologie (insel.ch)