Role of LDHB-dependent lactate metabolism in lung cancer initiation and chemotherapy resistance
Our goal is to investigate whether LDHB mediated lactate utilization contributes to tumor initiation and chemotherapy resistance in KRAS-mutant lung cancer and elucidate the underlying molecular mechanisms.
Role of LDHB-dependent lactate metabolism in lung cancer metastasis formation
We are investigating how LDHB-mediated lactate metabolism is associated with the formation of lung cancer metastases.
Development of a 1-2 punch therapy for the treatment of malignant pleural mesothelioma
Previously, we discovered that 5’-DFCR selectively targets chemotherapy-resistant lung cancer cells characterized by high CDA and TYMP expression (https://rdcu.be/clDAZ). Based on these findings, we are exploiting treatment induced cellular adaptations as novel targets in malignant pleural mesothelioma.