New Study Uncovers POLR1A as a Ferroptosis Gatekeeper—Opening New Avenues for Cancer Therapy
A new study in Redox Biology, with first author Tuo Zhang from the DBMR-OTM program, uncovers POLR1A as a key suppressor of ferroptosis in cancer cells. The research shows that inhibiting POLR1A boosts the effectiveness of GPX4 blockade, driving ferroptotic tumor cell death both in vitro and in vivo. These findings highlight a promising new strategy to enhance cancer therapy by targeting tumor iron metabolism and mitophagy.