Publications

2023

Brigger, D., Guntern, P., Jonsdottir, H. R., Pennington, L. F., Weber, B., Taddeo, A., Zimmer, G., Leborgne, N. G. F., Benarafa, C., Jardetzky, T. S., Eggel, A. Sex-specific differences in immune response to SARS-CoV-2 vaccination vanish with age. Allergy. 2023. PMID: 36680391.

Benito-Villalvilla C, de la Rocha-Muñoz A, López-Abente J, Eggel A, Bottoli I, Severin T, Woisetschläger M, Palomares O. Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation. Allergy. 2023. PMID: 36315052.

Loste A, Clément M, Delbosc S, Guedj K, Sénémaud J, Gaston AT, Morvan M, Even G, Gautier G, Eggel A, Arock M, Procopio E, Deschildre C, Louedec L, Michel JB, Deschamps L, Castier Y, Coscas R, Alsac JM, Launay P, Caligiuri G, Nicoletti A, Le Borgne M. PLoS One. 2023. PMID: 38055674

2022

Benito-Villalvilla C, de la Rocha-Muñoz A, López-Abente J, Eggel A, Bottoli I, Severin T, Woisetschläger M, Palomares O. Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation. Allergy. 2022 Oct 31. Epub ahead of print. PMID: 36315052.

Wood RA, Chinthrajah RS, Eggel A, Bottoli I, Gautier A, Woisetschlaeger M, Tassinari P, Altman P. The rationale for development of ligelizumab in food allergy. World Allergy Organ J. 2022 Sep 13;15(9):100690. 2022. PMID: 36185545.

Ardicli O, Carli KT, Satitsuksanoa P, Dreher A, Cusini A, Hutter S, Mirer D, Rückert B, Jonsdottir HR, Weber B, Cervia C, Akdis M, Boyman O, Eggel A, Brüggen MC, Akdis CA, van de Veen W. Exposure to avian coronavirus vaccines is associated with increased levels of SARS-CoV-2-cross-reactive antibodies. Allergy. 2022 Dec;77(12):3648-3662. Epub 2022 Jul 23. PMID: 35869837.

Horn MP, Jonsdottir HR, Brigger D, Damonti L, Suter-Riniker F, Endrich O, Froehlich TK, Fiedler M, Largiadèr CR, Marschall J, Weber B, Eggel A, Nagler M. Serological testing for SARS-CoV-2 antibodies in clinical practice: A comparative diagnostic accuracy study. Allergy. 2022 Jul;77(7):2090-2103. doi: 10.1111/all.15206. Epub 2022 Jan 11. PMID: 34986501.

2021

Zbären N, Brigger D, Bachmann D, Helbling A, Jörg L, Horn MP, Schmid JM, Hoffmann HJ, Kinet JP, Kaufmann T, Eggel A. A novel functional mast cell assay for the detection of allergies. J Allergy Clin Immunol. 2022. PMID: 34418424.

Pennington LF, Gasser P, Kleinboelting S, Zhang C, Skiniotis G, Eggel A, Jardetzky TS. Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun. 2021. PMID: 34862384.

Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr CR, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M. Accuracy of serological testing for SARS-CoV-2 antibodies: First results of a large mixed-method evaluation study. Allergy. 2021. PMID: 32997812.

Engeroff P, Plattner K, Storni F, Thoms F, Frias Boligan K, Muerner L, Eggel A, von Gunten S, Bachmann MF, Vogel M. Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model. J Allergy Clin Immunol. 2021. PMID: 33309740.

Pennington LF, Gasser P, Brigger D, Guntern P, Eggel A, Jardetzky TS. Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J Allergy Clin Immunol. 2021. PMID: 33991582.

2020

Guntern P, Eggel A. Past, present, and future of anti-IgE biologics. Allergy. 2020. PMID: 32249957.

Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbären N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nat Metab. 2020. PMID: 32694825.

Gasser P, Tarchevskaya SS, Guntern P, Brigger D, Ruppli R, Zbären N, Kleinboelting S, Heusser C, Jardetzky TS, Eggel A. The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nat Commun. 2020. PMID: 31913280

Delgado SJ, Dehmel S, Twisterling E, Wichmann J, Jonigk D, Warnecke G, Braubach P, Fieguth HG, Wilkens L, Dahlmann F, Kaup FJ, Eggel A, Knauf S, Sewald K, Braun A. Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue. J Allergy Clin Immunol. 2020. PMID: 31858993.